Doctors Recommend A New Drug For The Prevention Of HIV Infection

Doctors Recommend A New Drug For The Prevention Of HIV Infection.

Should males and females in threat of contracting HIV because they have risky sex be a pill to prevent infection, or will the medication encourage them to take even more sexual risks? After years of contend on this question, a new international study suggests the medication doesn't lead relations to stop using condoms or have more sex with more people. The research isn't definitive, and it hasn't changed the insight of every expert implant. But one of the study's co-authors said the findings support the drug's use as a road to prevent infection with HIV, the virus that causes AIDS.

And "People may have more partners or stop using condoms, but as well as we can tell, it's not because of taking the downer to prevent HIV infection ," said study co-author Dr Robert Grant, a older investigator with the Gladstone Institute of Virology and Immunology in San Francisco. The medication in mystery is called Truvada, which combines the drugs emtricitabine and tenofovir hgh up club. It's normally in use to treat people who are infected with HIV, but research - in vivid and bisexual men and in straight couples with one infected partner - have shown that it can lower the risk of infection in man who become exposed to the virus through sex.

However, it does not eliminate the risk of infection. The US Food and Drug Administration approved the medicate for prevention purposes in 2012. Few people seem to be taking it for banning purposes, however. Its manufacturer, Gilead, has disclosed that about 1700 people are taking the drug for that objective in the United States. In the new study, researchers found that expected rates of HIV and syphilis infection decreased in almost 2500 men and transgender women when they took Truvada.

The investigation participants, who all faced exuberant risk of HIV infection, were recruited in Peru, Ecuador, South Africa, Brazil, Thailand and the United States. Some of the participants took Truvada while others took an tranquil placebo. Those who believed they were taking Truvada "were just as repository as everyone else," Grant said, suggesting that they weren't more promising to stop using condoms or be more promiscuous because they believed they had extra care against HIV infection.

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Pain Is A Harbinger Of The Last Months Of Life At Half The Elderly

Pain Is A Harbinger Of The Last Months Of Life At Half The Elderly.

Pain is a commonly reported evidence during the keep on few years of life, with reports of slang pain in the arse increasing during the final few months, a new study has shown. Just over a fourth of clan reported being "troubled" by moderate or severe pain two years before they died, the researchers found. At four months before death, that copy had jumped to nearly half premature ejaculation josh and jess tell all. "This go into shows that there's a substantial burden of pain at the end of life, and not just the very end of life," said the study's guidance author, Dr Alexander K Smith, an assistant professor of prescription at the University of California, San Francisco, and a staff physician at the San Francisco VA Medical Center.

And "Arthritis was the sole biggest predictor of pain". Results of the study are published in the Nov 2, 2010 outlet of the Annals of Internal Medicine germany. Smith and his co-authors pointed out that numerous studies have been done on spasm associated with specific conditions, such as cancer, but that theirs may be the first to address injure from all conditions toward the end of life, a time when most people would say that being pain-free is a priority.

The study included intelligence on more than 4700 people who died while participating in a study of older adults called the Health and Retirement Study. The contemplation participants averaged 76 years old, included marginally more men than women and were mostly (83 percent) white. Every two years, they were asked if they were troubled by pain. If they answered yes, they were asked to rank their pain as mild, moderate or severe.

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Surgery to treat rectal cancer

Surgery to treat rectal cancer.

For many rectal cancer patients, the aspect of surgery is a worrisome reality, given that the manipulation can significantly impair both bowel and sexual function. However, a additional study reveals that some cancer patients may fare just as well by forgoing surgery in favor of chemotherapy/radiation and "watchful waiting". The conclusion is based on a review of data from 145 rectal cancer patients, all of whom had been diagnosed with originate I, II or III disease All had chemotherapy and radiation.

But about half had surgery while the others staved off the conduct in favor of rigorous tracking of their disease extension - sometimes called "watchful waiting womens. We believe that our results will encourage more doctors to judge this 'watch-and-wait' approach in patients with clinical complete response as an alternative to immediate rectal surgery, at least for some patients," superior study author Dr Philip Paty said in a tidings release from the American Society of Clinical Oncology (ASCO).

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Scientists Have Identified New Genes That Increase The Risk Of Alzheimer's Disease

Scientists Have Identified New Genes That Increase The Risk Of Alzheimer's Disease.

Scientists have pinpointed two genes that are linked to Alzheimer's virus and could become targets for budding treatments for the neurodegenerative condition. Genetic variants appear to piece an important on the part of in the development of Alzheimer's since having parents or siblings with the disease increases a person's risk women. It is estimated that one of every five persons grey 65 will develop Alzheimer's disease in their lifetime, the researchers added.

Genome-wide link studies are increasing scientists' understanding of the biological pathways underlying Alzheimer's disease, which may influence to new therapies, said study author Dr Sudha Seshadri, an accomplice professor of neurology at Boston University School of Medicine aunties. For now, man should realize that genes likely interact with other genes and with environmental factors.

Maria Carrillo, senior steersman of medical and scientific relations at the Alzheimer's Association, said that "these are the types of studies we be in want of in terms of future genetic analysis and things must be confirmed in much larger samples, as was done in this study". The check in is published in the May 12 issue of the Journal of the American Medical Association.

Although it was known that three genes are dependable for rare cases of Alzheimer's disease that run in families, researchers had been guaranteed of only one gene, apolipoprotein E (APOE), that increased the risk of the common type of Alzheimer's disease. Using a genome-wide alliance analysis study of 3006 people with Alzheimer's and 14642 clan without the disease, Seshadri's group identified two other genes associated with Alzheimer's disease, located on chromosomes 2 and 19.

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Use Of Smokeless Tobacco Increases The Risk Of Cancer, Stroke, Heart Attack

Use Of Smokeless Tobacco Increases The Risk Of Cancer, Stroke, Heart Attack.

Many smokers in the United States and its territories also use smokeless tobacco products such as snuff and masticate tobacco, a combine that makes quitting much more difficult, a unheard of federal turn over shows. Researchers analyzed data from the 2009 Behavioral Risk Factor Surveillance System and found that the rank of smokers who also use smokeless tobacco ranged from 0,9 percent in Puerto Rico to 13,7 percent in Wyoming. "The conflict against tobacco has taken on a new dimension as parts of the woods report high rates of cigarette smoking and smokeless tobacco use among adults vigora. The up-to-date data from the Centers for Disease Control and Prevention reveal disturbing trends in smoking pervasiveness as more individuals use multiple tobacco products to satisfy their nicotine addiction," American Heart Association CEO Nancy Brown said in a report released Thursday.

And "No tobacco by-product is safe to consume. The health hazards associated with tobacco use are well-documented and a new American Heart Association policy statement indicates smokeless tobacco products better the risk of fatal heart attack, fatal stroke and certain cancers" health. Among the 13 states with the highest rates of smoking, seven also had the highest rates of smokeless tobacco use.

In these states - Alabama, Alaska, Arkansas, Kentucky, Mississippi, Oklahoma and West Virginia - at least one of every nine men who smoked cigarettes also reported using smokeless tobacco. The rates in those states ranged from 11,8 percent in Kentucky to 20,8 percent in Arkansas. The governmental with the highest censure of smokeless tobacco use amongst of age c spear smokers was Wyoming (23,4 percent).

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Another Type Of Congenital Heart Disease May Be Cured By The Device And The Surgery

Another Type Of Congenital Heart Disease May Be Cured By The Device And The Surgery.

A congenital soul deficiency that was typically baneful three decades ago is no longer so deadly, thanks to new technologies and surgical techniques that put aside babies to survive well into adulthood, researchers report. A study in the May 27 problem of the New England Journal of Medicine compares the effectiveness of older and newer versions of devices aimed at fixing incompletely formed hearts quercetin hair loss treatment. The look at finds both performing equally well over three years.

It's a "landmark" study, "one that we've never had before in congenital goodness disease," said Dr Gail D Pearson, number one of the Adult and Pediatric Cardiac Research Program at the US National Heart, Lung and Blood Institute, which financed the effort herbal ms. The study, which compared two devices for keeping oxygen-carrying blood flowing in 549 children born with hearts incapable of doing it alone, has not yet produced through and through results favoring one seal over the other.

But the scrutinize is definitely just beginning. "Continuing follow-up will help us sort out the near- and long-term results". Study originator Dr Richard G Ohye, head of the University of Michigan pediatric cardiovascular surgery division, agreed. "Well be able to follow them to adulthood, and they will tutor us about the best way to undertake them". The children in the study were born with hearts that had a nonfunctioning - or nonexistent - left-wing ventricle, the chamber that pumps blood to the body. About 1000 such children are born in the United States each year, one in 5000.

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tag : children heart study results newer congenital blood shunt hearts

The Gene Of Early Puberty Passes From The Father To Children

The Gene Of Early Puberty Passes From The Father To Children.

Scientists announce they've identified a gene alteration behind a condition that causes children to weather puberty before the age of 9. The condition, known as central quick puberty, appears to be inherited via a gene passed along by fathers, say researchers reporting online June 5, 2013 in the New England Journal of Medicine duramale review in recife. Besides portion children with main precocious puberty, "these findings will open the door for a new accord of what controls the timing of puberty" generally, co-senior study author Dr Ursula Kaiser, manager of the endocrinology, diabetes and hypertension division at Brigham and Women's Hospital in Boston, said in a sanatorium news release.

According to the authors, the mutation leads to the start of puberty before age 8 in girls and before ripen 9 in boys. That's earlier than the typical onset of puberty, which begins in girls between ages 8 and 13 and in boys between ages 9 and 14 top 10 sperm count pills in india. The sanctum included genetic analyses of 40 consumers from 15 families with a history of early puberty.

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Women Suffer From Rheumatoid Arthritis More Often Than Men

Women Suffer From Rheumatoid Arthritis More Often Than Men.

Rheumatoid arthritis patients can on average manner forward to a much better quality of life today than they did 20 years ago, recent research suggests. The observation is based on a comparative multi-year tracking of more than 1100 rheumatoid arthritis patients. All had been diagnosed with the often seriously debilitating autoimmune condition at some point between 1990 and 2011 product. The reason for the brighter outlook: a combination of better drugs, better vex and mental health therapies, and a greater effort by clinicians to boost patient spirits while encouraging continued corporeal activity.

And "Nowadays, besides research on new drug treatments, enquire is mainly focused on examining which treatment works best for which patient, so therapy can become more 'tailor-made' and therefore be more effective for the unitary patient," said Cecile Overman, the study's lead author. Overman, a doctoral scholar in clinical and health psychology at Utrecht University in the Netherlands, expects that in another 20 years, rheumatoid arthritis patients will have the same distinction of life as anyone else "if the focus on the whole patient - not just the disease, but also the person's crazy and physical well-being - is maintained and treatment opportunities continue to evolve viagra. The contemplate was released online Dec 3, 2013 in Arthritis Care and Research.

In rheumatoid arthritis, the body's untouched system mistakenly attacks the joints, the Arthritis Foundation explains. The resulting swelling can damage joints and organs such as the heart. Patients face sudden flare-ups with warm, swollen joints, pain and fatigue. Currently there is no cure but a mix of drugs can treat symptoms and prevent the condition from getting worse.

Up to 1 percent of the world's inhabitants currently struggles with the condition, according to the World Health Organization. The current study was composed essentially of female rheumatoid arthritis patients (68 percent). Women are more prone to developing the acclimate than men. Patients ranged in age from 17 to 86, and all were Dutch.

Each was monitored for the commencement of disease-related physical and mental health disabilities for anywhere from three to five years following their opening diagnosis. Disease activity was also tracked to assess progression. The observed trend: a sensational two-decade drop in physical disabilities. The researchers also saw a decline in the incidence of solicitude and depression.

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Alzheimer's Disease Is Associated With A High Blood Pressure

Alzheimer's Disease Is Associated With A High Blood Pressure.

People pain from cardiovascular contagion who have lower-than-normal blood pressure may face a higher hazard of brain atrophy - the death of brain cells or connections between brain cells, Dutch researchers clock in June 2013. Such brain atrophy can lead to Alzheimer's bug or dementia in these patients powder. In contrast, similar patients with high blood pressure can behind the times brain atrophy by lowering their blood pressure, the researchers added.

Blood pressure is measured using two readings. The greatest number, called systolic pressure, gauges the pressure of blood unfixed through arteries. The bottom number, called diastolic pressure, measures the pressure in the arteries between heartbeats tablet. Normal blood coerce for adults is less than 120/80, according to the US National Heart, Lung, and Blood Institute.

For the study, 70 to 90 was considered reasonable diastolic blood pressure, while under 70 was considered low. "Our matter might suggest that patients with cardiovascular disease represent a subgroup within the communal population in whom low diastolic blood pressure might be harmful," said researcher Dr Majon Muller, an epidemiologist and geriatrician at VU University Medical Center in Amsterdam.

On the other hand, lowering blood pressurize in kinsfolk with high blood pressure might slow brain atrophy. "Our findings could advert to that blood pressure lowering is beneficial in patients with higher blood put the screws on levels, but one should be cautious with further blood pressure lowering in patients who already have low diastolic blood pressure".

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The Wounded Soldier Was Saved From The Acquisition Of Diabetes Through An Emergency Transplantation Of Cells

The Wounded Soldier Was Saved From The Acquisition Of Diabetes Through An Emergency Transplantation Of Cells.

In the inception functioning of its kind, a wounded warrior whose damaged pancreas had to be removed was able to have his own insulin-producing islet cells transplanted back into him, penurious him from a life with the most severe form of type 1 diabetes In November 2009, 21-year-old Senior Airman Tre Porfirio was serving in a reserved arrondissement of Afghanistan when an insurgent who had been pretending to be a soldier in the Afghan army shot him three times at thick as thieves range with a high-velocity rifle.

After undergoing two surgeries in the field to stop the bleeding, Porfirio was transferred to the Walter Reed Army Medical Center in Washington, DC As component of the surgery in the field, a division of Porfirio's stomach, the gallbladder, the duodenum, and a section of his pancreas had been removed advice on taking hgh. At Walter Reed, surgeons expected that they would be reconstructing the structures in the abdomen that had been damaged.

However, they promptly discovered that the uneaten portion of the pancreas was leaking pancreatic enzymes that were dissolving parts of other organs and blood vessels, according to their turn up in the April 22 issue of the New England Journal of Medicine. "When I went into surgery with Tre, my goal was to reconnect everything, but I discovered a very dire, risky situation," said Dr Craig Shriver, Walter Reed's chief of imprecise surgery.

So "I knew I would now have to remove the remainder of his pancreas, but I also knew that leads to a life-threatening fabricate of diabetes. The pancreas makes insulin and glucagon, which take out the extremes of very far up and very low blood sugar". Because he didn't want to leave this soldier with this life-threatening condition, Shriver consulted with his Walter Reed colleague, resettle surgeon Dr Rahul Jindal.

Jindal said that Porfirio could be given a pancreas transplant from a matched donor at a later date, but that would call lifelong use of immune-suppressing medications. Another option was a transplant using Porfirio's own islet cells - cells within the pancreas that bring about insulin and glucagon. The procedure is known as autologous islet apartment transplantion.

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tag : cells islet porfirio pancreas diabetes walter insulin procedure surgery



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