A new cause of heart disease

A new cause of heart disease.


A genetic altering occurring in a significant platoon of people with heart disease appears to raise the odds for heart disparage or death by 38 percent, a new study suggests. This "stress reaction gene," which Duke University scientists time past linked to an overproduction of cortisol, a stress hormone that can sham heart risks, was found in about 17 percent of men and 3 percent of women with heart disease fav store net. The rejuvenated finding, also from Duke researchers, offers a potential new explanation for a biological predisposition to sensitivity disease and early death, the study authors said.



The research may sooner lead to personalized therapies for heart disease patients. "This is very exciting, but it's very preliminary. It certainly merits further investigation," said office author Beverly Brummett, an confederate professor of psychiatry and behavioral sciences at the Duke University School of Medicine reviews. "Down the line, if the findings were replicated, then the next initiative would be to test people on a widespread basis for the gene and watch them more closely".



The bookwork was published Dec 18, 2013 in the journal PLoS One. Heart disorder is the No. 1 killer of Americans. Its most common cause is the narrowing of coronary arteries, which can prima donna to heart attacks, according to the US National Library of Medicine. About 600000 people in the United States go for a burton each year due to heart disease. Brummett and her colleagues ran genetic analyses on more than 6100 fair-skinned men and women who were part of a large database of Duke heart catheterization patients.



Two-thirds of the participants were men. Patients carrying the genetic deviating experienced the highest rates of marrow attacks and deaths over an average follow-up period of six years. Despite adjusting the results for kindness disease risk factors such as age, obesity and smoking history, the genetic mark was associated with a 38 percent higher risk of heart attack and death. This warm of association, however, does not necessarily prove a cause-and-effect relationship.



Dr Nieca Goldberg, medical captain of New York University's Women's Heart Program, said the research was "very exciting. There's a lot of blab going on about personalized medicine and we're trying to really individualize our therapies," said Goldberg, who was not affected in the study. "This identifies a genetic trait that predisposes woman in the street to heart disease, and once this is tailored a little more and we have more research, it would be exciting if this genetic test became commercially available," said Goldberg, who is also a spokesperson for the American Heart Association worldplusmed.net. Goldberg said it would be effective to recollect how frequently the gene variant occurs in other ethnic groups, such as blacks, Asians and Latinos, since all of the bone up participants were white.

tag : heart disease genetic goldberg percent patients medicine women exciting

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ivankuleshov

Author:ivankuleshov
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