Excess Weight Is Not The Verdict

Excess Weight Is Not The Verdict.


For the triumph time, researchers have shown that implanting electrodes in the brain's "feeding center" can be safely done - in a offer to bring out a new treatment option for severely obese people who fail to shed pounds even after weight-loss surgery. In a beginning study with three patients, researchers in June 2013 found that they could safely use the therapy, known as crafty brain stimulation (DBS). Over almost three years, none of the patients had any straight-faced side effects, and two even lost some weight - but it was temporary read more here. "The cardinal thing we needed to do was to see if this is safe," said lead researcher Dr Donald Whiting, depravity chairman of neurosurgery at Allegheny General Hospital in Pittsburgh.



And "We're at the point now where it looks equal it is". The study, reported in the Journal of Neurosurgery and at a meeting this week of the International Neuromodulation Society in Berlin, Germany, was not meant to study effectiveness found here. So the big remaining call in is, can deep brain stimulation actually promote lasting weight loss?



"Nobody should get the intimation that this has been shown to be effective. This is not something you can go ask your doctor about". Right now, deep planner stimulation is sometimes used for tough-to-treat cases of Parkinson's disease, a movement disorder that causes tremors, ceremonious muscles, and balance and coordination problems. A surgeon implants electrodes into established movement-related areas of the brain, then attaches those electrodes to a neurostimulator placed under the skin near the collarbone.



The neurostimulator continually sends teeny-weeny electrical pulses to the brain, which in turn interferes with the anomalous activity that causes tremors and other symptoms. What does that have to do with obesity? In theory deep wit stimulation might be able to "override" brain signaling involved in eating, metabolism or feelings of fullness.



Research in animals has shown that electrical stimulation of a separate area of the brain - the lateral hypothalamic area - can stimulate weight loss even if calorie intake stays the same. The new ponder marks the first time that deep brain stimulation has been tried in that brain region. And it's an well-connected first step to show that not only could these three severely obese people get through the surgery, but they also seemed to have no crucial effects from the brain stimulation, said Dr Casey Halpern, a neurosurgeon at the University of Pennsylvania who was not tangled in the research.



And "That shows us this is a therapy that should be studied further in a larger trial," said Halpern, who has done animalistic research exploring the idea of using deep brain stimulation for obesity. "Obesity is a foremost problem and current therapies, even gastric bypass surgery, don't always work. There is a medical needfulness for new therapies".



The three patients in Whiting's study were examples of that medical need. All were coldly obese and had failed to shed weight after gastric bypass surgery - the trendy last-ditch treatment option. During the study period, the patients did have some attitude effects from deep brain stimulation - nausea, anxiety and feeling "too acrid or flushed" - but they were short-lived, the researchers said.



And there was some evidence that the brain stimulation was having effects. In lab tests, Whiting's group found that the deep brain stimulation seemed to urge short-lived spikes in resting metabolism. Then, after the deep brain stimulation was programmed to the settings that seemed to support metabolism, two patients shed some pounds - 12 percent to 16 percent of what they weighed before the DBS settings were "optimized".



And "There was some influence loss, but it was transient". Now a essential question is, what is the right setting for the deep brain stimulation to foster lasting weight loss? Whiting said his team is continuing to follow these three patients to inspect to figure that out - and to keep monitoring safety. Although deep brain stimulation is considered a usually safe therapy for the right patients, it is a major undertaking that requires two surgeries - one to graft electrodes in the brain and another to place the neurostimulator.



The potential risks include infection, a blood clot or bleeding in the brain, or an allergic effect to the DBS parts. If extensive brain stimulation ever does become an option for managing severe obesity he would expect it only to be used when all else fails. "This would positively be a last resort.



So "At first, it would absolutely be a last-ditch option," neurosurgeon Halpern said. But it's also achievable that deep brain stimulation could become an add-on therapy, cast-off after gastric bypass for some patients whose weight does not fall - or even an alternative in certain cases where alternative surgery is too risky. Medtronic provided the deep brain stimulation hardware for the study and funded the work related site. One of Whiting's co-researchers is employed by the company.

tag : brain stimulation patients weight study three whiting surgery electrodes

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ivankuleshov

Author:ivankuleshov
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