Use Of Medicines For Epilepsy During Pregnancy Can Cause A Risk To The Child

Use Of Medicines For Epilepsy During Pregnancy Can Cause A Risk To The Child.


Pregnant women with epilepsy who are alluring carbamazepine (Tegretol) to jurisdiction seizures may be at a minor extent increased chance of having an infant with spina bifida, a strange go into finds. Spina bifida is a fit in which the bones of the spicula do not close but the spinal line remains in place, usually with hull covering the defect cemu sluzi viagra. Most children will dearth lifelong treatment for problems arising from harm to the spinal cord and spinal nerves.



And "For women with epilepsy, possession control during pregnancy is very important," said margin researcher Lolkje de Jong-van den Berg, from the diremption of druggist's at the University of Groningen in the Netherlands. "Our memorize can help in decisions regarding whether carbamazepine should be the poison of choice in pregnancy" Nuzen hair oil store in delhi. However, the best choice regarding treatment can be chosen only on an individual main ingredient by the woman and her neurologist before pregnancy, weighing the benefits of epilepsy authority over against the risk of birth defects, de Jong-van den Berg said.



The publish is published in the Dec 3, 2010 online issue of the BMJ. For the study, de Jong-van den Berg's span reviewed existing examination to judge the peril of birth defects among women fascinating Tegretol veetids. The researchers found that infants of women engaging Tegretol were 2,6 times more credible to have spina bifida, compared with women not irresistible any anti-epileptic medication.



However, the risk associated with Tegretol was less than with another anti-epileptic drug- valproic acid (Depakene). In fact, Tegretol was less dicey than valproic acid when it came to other line defects such as hypospadias, where a boy's urinary split develops in the diabolic role of the penis or in the scrotum. "Carbamazepine is specifically consanguineous to an increased risk of spina bifida," de Jong-van den Berg said. "But you have to withhold in feeling that the absolute risk is small".



For Tegretol infatuated in the first trimester, the overall jeopardy of a major malformation was 3,3 percent, the library authors reported. The same group of researchers found in another study, published this year in the New England Journal of Medicine, that women enchanting valproic acid were six times more odds-on to have an infant with spina bifida and seven times more in all probability have an infant with hypospadias, compared with women using other anti-epileptic drugs.



The researchers admit with a support from the American Academy of Neurology that valproic acid should be avoided in pregnancy if possible. Dr Orrin Devinsky, gaffer of the Epilepsy Center at NYU Langone Medical Center, said that "for women of childbearing age, these drugs typify a risk".



Women beggary to compare the hazard and gain of these drugs, he explained. Women with epilepsy be in want of to deferment on an anti-epileptic deaden while they are pregnant, Devinsky said. "The gamble of seizure to themselves and potentially to their fetus is greater than the jeopardize of anti-epileptic drugs," he added.



There are surrogate drugs, specifically lamotrigine (Lamictal) and levetiracetam (Keppra). However, there is barely facts on any dangers associated with these drugs during pregnancy, Devinsky noted. Another expert, Dr Kimford Meador, a professor of neurology at Emory University School of Medicine, said women insufficiency to be acquainted with the risks associated with Tegretol Drugstore in qatar selling penis enlargement product. "If a handmaiden is of childbearing quiescent and you are prescribing this drug, that's when the parley needs to occur," Meador said.

tag : women tegretol drugs epilepsy pregnancy spina bifida epileptic valproic defects

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