The Flu Vaccine Is Little Effect On Men

The Flu Vaccine Is Little Effect On Men.

The flu vaccine is less moving for men than women, and researchers at Stanford University assume they've figured out why. The virile hormone testosterone causes genes in the immune way to produce fewer antibodies, or defense mechanisms, in response to the vaccine, they found "Men, typically, do worse than women in exempt response to infection and vaccination," said Stanford research friend David Furman, the lead study investigator.

For instance, men are more susceptible to bacterial, viral, fungal and parasitic infection than women. And men's untouched systems don't return as robustly as women's to vaccinations against flu, yellow fever, measles, hepatitis and many other diseases, Furman said breast. For the study, published online Dec 23, 2013 in the Proceedings of the National Academy of Sciences, the researchers analyzed the blood of nearly 90 adults after they received a seasonal flu shot.

Men with the highest testosterone levels had the worst return to the flu vaccine across the board, Furman said. Testosterone is tied to archetypal masculine sex characteristics, such as muscle strength, beard wen and risk-taking. "We found a set of genes in men that when activated caused a poor retort to the vaccine, but were not involved in female response. Some of these genes are regulated by testosterone".

It's testosterone's bring about on these genes that causes the poor vaccine response, Furman explained. "This has a lot of implications for vaccine development," Furman said. Vaccine feedback might be better if men were given twice the dose, he suggested, or it is possible that if testosterone levels were reduced. The whole picture isn't really clear or simple, he noted. Men's weaker reply to the flu vaccine is only seen for some strains of flu.

So "We don't advised of why," Furman said. One expert doesn't think testosterone by oneself explains the difference in vaccine response between men and women. "There is more involved, but testosterone does feign the immune response," said Dr Alan Mensch, medical director at North Shore-LIJ Plainview Hospital in Plainview, NY Mensch doesn't suppose it's necessary to escalation vaccine doses for men. Rather, he thinks women can get by with a lower dose.

And "There isn't a dissimilitude in the amount of protection from flu. Women just don't need as much vaccine," Mensch said. In this study, which confusing 53 women and 34 men, researchers found that, in general, women had a stronger antibody reaction to the vaccine. This was consistent with findings from other studies, the authors noted. However, men with rude testosterone levels had an antibody response similar to women.

Furman's tandem also noticed that the activity of certain genes in men, but not women, was associated with a weakened antibody rejoinder to the flu vaccine. When they looked at male testosterone levels in relation to gene activity, they dictum increased activation of the Module 52 genes in men with high testosterone levels. This resulted in reduced antibody development for the flu, the researchers concluded.

But in women, activation levels of Module 52 genes had no significant obtain on flu antibody levels, the inspect authors noted. Some Module 52 genes are known to be related to the immune system. The connections between these genes and testosterone might be a objective for further study and drug development, Furman said.

One unanswered dispute is what evolutionary purpose is served by having testosterone connected to the immune system, Furman said. It's conceivable that an overly robust immune response might be more dangerous than the disorder itself. For example, women with their robust immune responses are twice as likely as men to desire from infections that invade the blood system, Furman explained vitomol. So maybe a degree less robust immune system can be lifesaving for men, he suggested.

tag : vaccine women testosterone furman genes response immune levels antibody

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